Causality is a main philosophical category. In the history of philosophy, from the ancient times causality has had unquestionable ontological status, which means it was recognized as existing in reality, regardless of any other impacts. But modern times have changed this situation, and the Scottish philosopher David Hume proved even that causality as such does not exist in reality and it is only a function of the human mind, which tends to combine with another elements emerging in the order of time-space facts. Of course in human relationships a causal factor appears in a somewhat different way, as a result of the relationships between people, where it is obtained in a more or less rational fashion, informed by people's activities. Something similar happens in the study of international relations, where rational - but also emotional - factors operate at the state level. It follows that in international relations causality should also have philosophical status, though not in an ontological sense, but more in an epistemological sense, that is, as something that explains and leads to understanding the actions and intentions of the various actors of international relations. In my paper I attempt to determine the relationships that occur between the ontological recognition or rejection of the real existence of causality, and the role of epistemological causality in describing international relations of the modern world.